Benzoic Acid → 2-(2-(Benzamidomethyl)-5-carbamimidoylphenylamino)acetic acid

反応式

Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=C(C)O[N:11]=2)=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19].[C:28](O)(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[C:28]([NH:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[NH:11])[NH2:14])=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([OH:20])=[O:19])(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

参加物

反応物 2

HCID 243Benzoic Acid

HCID 69490392Benzyl 2-(2-(aminomethyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetate hydrochloride

生成物 1

HCID 113018252-(2-(Benzamidomethyl)-5-carbamimidoylphenylamino)acetic acid

実験手順

Compound 58d was reacted with benzoic acid and subsequently hydrogenated according to the the procedure described in Example 58, to give Example 62. ESI-MS m/e 327.5 (M+1).

後処理

customto give Example 62

出典と根拠

ORDレコード: ord-35a8daa004d34cc49b6b730574e02279
出典データセット: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07247654B2

反応ノート

読み込み中…