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3-Carbomethoxy-4-(3-methoxyphenyl)-3-butenoic acid → 3-Carbomethoxy-4-(3-methoxyphenyl)butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Carbomethoxy-4-(3-methoxyphenyl)-3-butenoic acid | HCID 589607 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Carbomethoxy-4-(3-methoxyphenyl)butanoic acid | HCID 10658447 | 83.1% |
反応手順
A solution of 21.1 g (84 mmol) of 3-carbomethoxy-4-(3-methoxyphenyl)-3-butenoic acid in 100 ml of acetic acid with 2.11 g of 10% Pd on carbon is shaken under H2 atmosphere until H2 uptake ceases (approximately 4 hours). This is filtered through celite and the filtrate concentrated in vacuo several times from toluene to afford 17.6 g of 3-carbomethoxy-4-(3-methoxyphenyl)butanoic acid in the form of a yellow oil which is used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05468898 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-a131f54ab91a46f0a140d8f163f67720 |
| 出典メモ | uspto-grants-1995_11 |