Dimethylformamide → HCID 58913661、化合物

HRID 1296951ノート

反応式

HRID 1296951 の反応式
[Cl:1][C:2]1[C:3]([OH:21])=[C:4]([CH3:20])[C:5]([OH:19])=[C:6]([C:8](=[O:18])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[CH:7]=1.CN(C=O)C.C([O-])([O-])=O.[K+].[K+].[C:33](OC(=O)C)(=O)[CH3:34]>O>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5](=[C:4]([CH3:20])[C:3]=1[OH:21])[O:19][C:33]([CH3:34])=[C:9]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)[CH:8]2[OH:18]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 58913540HCID 58913540、化合物

生成物 1

HCID 58913661HCID 58913661、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 1-(5-chloro-2,4-dihydroxy-3-methyl-phenyl)-2-(4-methoxy-phenyl)-ethanone (1 eq) in an. DMF (7 ml) was added K2CO3 (3 eq). Acetic anhydride (3 eq) was added dropwise to the solution, which was then refluxed under nitrogen whilst stirring for 5 h. The solution was taken up in water and extracted using ethyl acetate, dried over MgSO4 and concentrated in vacuo to give 6-chloro-3-(4-methoxy-phenyl)-2,8-dimethyl-4H-chromene-4,7-diol as a crystalline solid.

後処理

  1. temperaturewas then refluxed under nitrogen
  2. extractionextracted
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-bf85aa3446604a58a04d70bd7402924b
出典データセット
uspto-grants-2007_07
特許番号
US07247734B2

反応ノート

読み込み中…