Sodium Bicarbonate → HCID 11416722、化合物

HRID 1296955ノート

反応式

HRID 1296955 の反応式
C[O:2][C:3]([C:5]1[O:6][C:7]2[C:12]([C:13](=[O:23])[C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)=[CH:11][C:10]([Cl:24])=[C:9]([OH:25])[CH:8]=2)=[O:4].C([O-])(O)=O.[Na+]>CO>[Cl:24][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][C:9]=1[OH:25])[O:6][C:5]([C:3]([OH:4])=[O:2])=[C:14]([C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[C:13]2=[O:23]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 11233736HCID 11233736、化合物

生成物 1

HCID 11416722HCID 11416722、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6-Chloro-7-hydroxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid methyl ester was taken up in a 2:1 mixture of sat. NaHCO3 (aq): Methanol and all was heated at 65° C. for 5 hours. The solution was cooled to room temperature and concentrated in vacuo to remove the methanol. The residual aqueous solution was acidified with 1M HCl (aq) and a buff coloured precipitated dropped out of solution. This was collected by vacuum filtration, washed with water and with diethyl ether, to give 6-chloro-7-hydroxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid.

後処理

  1. concentrationconcentrated in vacuo
  2. customto remove the methanol
  3. customa buff coloured precipitated
  4. additiondropped out of solution
  5. filtrationThis was collected by vacuum filtration
  6. washwashed with water and with diethyl ether

出典と根拠

ORDレコード
ord-bb47942497dc468684708e317f892498
出典データセット
uspto-grants-2007_07
特許番号
US07247734B2

反応ノート

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