Triethylamine → 2,2-Diphenylethyl 3-oxobutanoate

HRID 1297019

反応式

HRID 1297019 の反応式
[C:1]1([CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH2:23]=[C:24]1[O:28][C:26](=[O:27])[CH2:25]1.C(=O)([O-])O.[Na+]>C1(C)C=CC=CC=1>[C:26]([O:9][CH2:8][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)(=[O:27])[CH2:25][C:24]([CH3:23])=[O:28]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 12661DiketeneHCID 74662beta-Phenylphenethyl alcoholHCID 516892Sodium Bicarbonate

生成物 1

HCID 40765052,2-Diphenylethyl 3-oxobutanoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

500 mg (2.52 mmol) of 2,2-diphenylethanol was dissolved in 10 ml of toluene. 382 mg (3.78 mmol) of triethylamine was added to the obtained solution, and they were stirred at room temperature for 1 hour. 386 mg (3.03 mmol) of diketene was added to the obtained mixture under cooling with ice, and then they were stirred under heating at 100° C. for 2 hours. After the addition of saturated aqueous sodium hydrogencarbonate solution followed by the extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the unpurified title compound.

後処理

  1. temperatureunder cooling with ice
  2. stirringthey were stirred
  3. temperatureunder heating at 100° C. for 2 hours
  4. extractionfollowed by the extraction with ethyl acetate
  5. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-16d1b5b64c60448a9becba0e62027330
出典データセット
uspto-grants-2007_07
特許番号
US07247645B2

関連ノート

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