関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Naphthol | HCID 8663 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 7-Aminodeacetoxycephalosporanic acid | HCID 33498 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Penicillin G | HCID 5904 | — |
反応手順
The pH value of a mixture (slurry) of D-PGA.1/2H2SO4 (74.7 g, 0.375 mol), 7-ADCA (21.4 g, 0.10 mol), and 2-naphthol (10.8 g, 0.075 mol, particle size <100 μm) in approximately 300 ml of water was adjusted to 6.7 by addition of 4M ammonium hydroxide. Water was added to 400 ml followed by immobilized E. coli Penicillin G acylase prepared as described above (50 g on dry basis suspended in water to a total of 100 ml), and the mixture was stirred at 25° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05470717 |
|---|
| 出典データセット | uspto-grants-1995_11 |
|---|
| ORD ID | ord-2576228db0324c0b98d3a4546f045b56 |
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| 出典メモ | uspto-grants-1995_11 |
|---|
