N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine → N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine
反応式
C(O[C@H]1CNC[C@H]1NC1C(CC)=NC(C2C(C)=NC(OC)=CC=2)=C(CC)N=1)C.[CH2:29]([C:31]1[C:32]([NH:51][C@H:52]2[C@@H:56]([O:57][CH2:58][CH3:59])[CH2:55][N:54](C(OCC3C=CC=CC=3)=O)[CH2:53]2)=[N:33][C:34]([CH2:49][CH3:50])=[C:35]([C:37]2[C:38]([C:45]([F:48])([F:47])[F:46])=[N:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=2)[N:36]=1)[CH3:30]>>[CH2:58]([O:57][C@H:56]1[CH2:55][NH:54][CH2:53][C@H:52]1[NH:51][C:32]1[C:31]([CH2:29][CH3:30])=[N:36][C:35]([C:37]2[C:38]([C:45]([F:48])([F:47])[F:46])=[N:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=2)=[C:34]([CH2:49][CH3:50])[N:33]=1)[CH3:59]参加物
3
反応物 2
生成物 1
実験手順
Following the procedure for the preparation of N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting benzyl (3R,4S)-3-({3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl}amino)-4-ethoxypyrrolidine-1-carboxylate provided the title compound as an amber oil. 1H NMR (CDCl3) δ 1.13, 1.28, 2.41, 2.69, 3.14, 3.37, 3.51, 3.66˜3.75, 4.04, 4.16, 4.69, 5.29, 6.96, 7.54; IR (liq.) 2975 (s), 2417 (b), 2177 (b), 2029 (w), 1923 (w), 1609 (s), 1565 (s), 1479 (s), 1400 (s), 1341 (s), 1278 (s), 1239 (s), 1192 (s), 1177 (s), 1138 (s) cm−1.
出典と根拠
- ORDレコード
- ord-824378dbbcc240f5b9fd37434ee5084c
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07250418B2
反応ノート
読み込み中…