N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine → 5-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

HRID 1297296ノート

反応式

HRID 1297296 の反応式
C(O[C@H]1CNC[C@H]1NC1C(CC)=NC(C2C(C)=NC(OC)=CC=2)=C(CC)N=1)C.[CH3:29][O:30][C:31]1[C:36]([C:37]2[N:38]=[C:39]([CH2:64][CH3:65])[C:40]([NH:45][C@H:46]3[C@@H:50]([O:51][CH2:52][CH3:53])[CH2:49][N:48](C(OCC4C=CC=CC=4)=O)[CH2:47]3)=[N:41][C:42]=2[CH2:43][CH3:44])=[CH:35][CH:34]=[C:33]([O:66][CH3:67])[N:32]=1>>[CH3:29][O:30][C:31]1[C:36]([C:37]2[N:38]=[C:39]([CH2:64][CH3:65])[C:40]([NH:45][C@H:46]3[C@@H:50]([O:51][CH2:52][CH3:53])[CH2:49][NH:48][CH2:47]3)=[N:41][C:42]=2[CH2:43][CH3:44])=[CH:35][CH:34]=[C:33]([O:66][CH3:67])[N:32]=1

参加物

3

反応物 2

HCID 58914560N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amineHCID 58914561benzyl (3R,4S)-3-{[5-(2,6-dimethoxypyridin-3-yl)-3,6-diethylpyrazin-2-yl]amino}-4-ethoxypyrrolidine-1-carboxylate

生成物 1

HCID 589145715-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

実験手順

Following the procedure for the preparation of N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting benzyl (3R,4S)-3-{[5-(2,6-dimethoxypyridin-3-yl)-3,6-diethylpyrazin-2-yl]amino}-4-ethoxypyrrolidine-1-carboxylate provided the title compound as an amber oil. 1H NMR (400 MHz, CDCl3) δ) 7.53, 6.42, 5.29, 4.52, 4.04, 3.98, 3.92, 3.66, 3.51, 3.40, 3.21, 3.12, 2.91, 2.72, 2.48, 1.28, 1.18; IR (liq.) 2972, 2418 (w), 2184 (w), 2036 (w), 1993 (w), 1603, 1581 (s), 1564, 1477 (s), 1423, 1395, 1376 (s), 1313 (s), 1233, 1022 cm−1 HRMS (ESI) calcd for C21H31N5O3+H1 402.2505. found 402.2516.

出典と根拠

ORDレコード
ord-f70135093c4b47ccaa1ed940732cde07
出典データセット
uspto-grants-2007_07
特許番号
US07250418B2

反応ノート

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