Methylamine → 5-Bromo-2-(methylaminocarbonylmethyl)aminopyridine

HRID 1297381ノート

反応式

HRID 1297381 の反応式
[CH3:1][NH2:2].[Br:3][C:4]1[CH:5]=[CH:6][C:7]([NH:10][CH2:11][C:12]([O:14]C)=O)=[N:8][CH:9]=1>CO>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([NH:10][CH2:11][C:12]([NH:2][CH3:1])=[O:14])=[N:8][CH:9]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetate

生成物 1

HCID 221390975-Bromo-2-(methylaminocarbonylmethyl)aminopyridine収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 2.0 M methylamine in MeOH (75 mL) was added to 5-bromo-2-(methoxycarbonylmethyl)aminopyridine (2.9 g, 12 mmole). The reaction was stirred for 24 h then was concentrated to dryness. The residue was triturated with 10% petroleum ether/Et2O (100 mL), then was collected and dried under vacuum to give the title compound (2.96 g, 100%) as an off-white solid: MS (ES) m/e 244.2 (M+H)+.

後処理

  1. concentrationthen was concentrated to dryness
  2. customThe residue was triturated with 10% petroleum ether/Et2O (100 mL)
  3. customwas collected
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-7bf172d8077f4adeba72ea15274e98ba
出典データセット
uspto-grants-2007_07
特許番号
US07250424B2

反応ノート

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