Hexahydro-1,4-diazepine → 1-[2-(Benzhydryloxy)ethyl]-1,4-diazepane

反応式

[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:8][CH2:9][CH2:10]Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:8][CH2:9][CH2:10][N:18]2[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 2

HCID 68163Hexahydro-1,4-diazepine

HCID 141724Benzhydryl 2-chloroethyl ether

生成物 1

HCID 27354411-[2-(Benzhydryloxy)ethyl]-1,4-diazepane収率 68%

実験手順

Following a procedure similar to that described in Preparation 1, but using 2-(diphenylmethoxy)ethyl chloride and homopiperazine, the title compound was obtained ina yield of 68%.

後処理

customthat described in Preparation 1

出典と根拠

ORDレコード: ord-91f9b464e08e49e9994f52ec74cded33
出典データセット: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05470851

反応ノート

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