Ethylamine hydrochloride → 2-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

反応式

[CH2:1]([NH-])C.Cl.C(N)C.[O:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17][C:18]3[N:40]=[CH:39][CH:38]=[CH:37][C:19]=3[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([CH3:36])([C:32](=[O:35])[NH:33][CH3:34])[CH3:31])=[CH:26][CH:25]=3)=[O:21])=[CH:16][C:11]=2[O:10][CH2:9]1>>[O:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17][C:18]3[N:40]=[CH:39][CH:38]=[CH:37][C:19]=3[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([C:32](=[O:35])[NH:33][CH2:34][CH3:1])([CH3:36])[CH3:31])=[CH:26][CH:25]=3)=[O:21])=[CH:16][C:11]=2[O:10][CH2:9]1

参加物

反応物 3

HCID 11198Ethylamine hydrochloride

HCID 187872Ethanaminide

HCID 101146022-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-methyl-1-methylcarbamoyl-ethyl)-benzyl]-nicotinamide

生成物 1

HCID 102265372-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

実験手順

The remaining portion of the tetrahydrofuran solution from Example 5a (10 mL) was converted to the ethyl amide with ethylamine hydrochloride using the same procedure.

出典と根拠

ORDレコード: ord-5f95505d68174f8797f4db0ccf53eee8
出典データセット: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07250518B2

反応ノート

読み込み中…