Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1298838

反応式

HRID 1298838 の反応式
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C1CCC(P(CCP(C2CCCCC2)C2CCCCC2)C2CCCCC2)CC1.CC(C)(C)c1ccc(C=[CH](c2ccc(C(C)(C)C)cc2)->[Ni](<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)cc1.COCCOCCOC.O=P([O-])([O-])[O-].[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

参加物

9

反応物 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

生成物 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine収率 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine収率 0%

試薬・触媒・溶媒 4

HCID 21226062CID 21226062試薬HCID 5342021,2-Bis(dicyclohexylphosphino)ethane触媒HCID 178440864HCID 178440864、化合物触媒HCID 8150Diglyme溶媒5 回

反応条件

温度
60 °C

後処理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード
ord-3805a1e5ca6b4a04afcc63da4a41c449
出典データセット
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
元リンク
出典を表示

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