Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1301693

反応式

HRID 1301693 の反応式
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C=[CH](C)->[Pd]1<-[Cl][Pd](<-[Cl]1)<-[CH](=C)C.COCCOCCOC.C[O-].Clc1ccc(P(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1.[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

参加物

9

反応物 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

生成物 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine収率 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine収率 0%

試薬・触媒・溶媒 4

HCID 10942334Sodium Methoxide試薬HCID 70874Tris(4-chlorophenyl)phosphine触媒HCID 178461822HCID 178461822、化合物触媒HCID 8150Diglyme溶媒5 回

反応条件

温度
60 °C

後処理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード
ord-3e15f904e7f849ee97408a15e83c7df8
出典データセット
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
元リンク
出典を表示

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