2-Acetylbenzofuran → 1-(2-Benzofuryl)-4,4,5,5,5-pentafluoro-1,3-pentanedione

反応式

[C:1]([C:4]1[O:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2].[F:13][C:14]([F:24])([F:23])[C:15]([F:22])([F:21])[C:16](OCC)=[O:17]>>[O:5]1[C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=[C:4]1[C:1](=[O:3])[CH2:2][C:16](=[O:17])[C:15]([F:22])([F:21])[C:14]([F:24])([F:23])[F:13]

参加物

反応物 2

HCID 154352-Acetylbenzofuran

HCID 67928Propanoic acid, 2,2,3,3,3-pentafluoro-, ethyl ester

生成物 1

HCID 101495991-(2-Benzofuryl)-4,4,5,5,5-pentafluoro-1,3-pentanedione

実験手順

The compound was synthesized according to example 1 using 2-acetylbenzofuran and ethyl pentafluoropropionate as starting materials. The product was crystallized from petroleum ether. 1H NMR (CDCl3): 6.75 (s, 1 H); 7.35 (ddd, 1H, J=0.9 & 7.1 & 7.9 Hz); 7.51 (ddd, 1H, J=1.3 & 7.1 & 8.4 Hz); 7.58-7.60 (m, 1 H); 7.67 (d, 1H, J=0.9 Hz); 7.71-7.73 (m, 1 H). IR (film): 1614 (C═O); 1211, 1200 (C—F).

後処理

customThe compound was synthesized
customThe product was crystallized from petroleum ether

出典と根拠

ORDレコード: ord-6dbe56fcc3384380ac36ed4731f1fff4
出典データセット: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07381567B2

反応ノート

読み込み中…

参加物