Benzenesulfonyl chloride → 4-(2-Benzenesulfonylamino-thiazol-4-yl)-benzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH2:15])[S:13][CH:14]=2)=[CH:6][CH:5]=1.[C:17]1([S:23](Cl)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[C:12]([NH:15][S:23]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:25])=[O:24])[S:13][CH:14]=2)=[CH:8][CH:9]=1参加物
5
実験手順
A mixture of 4-(2-amino-thiazol-4-yl)-benzoic acid methyl ester (1.17 g, 5 mmol), benzenesulfonyl chloride (1.06 g, 6 mmol) and 4-dimethylaminopyridine (2.20 g, 18 mmol) in CH2Cl2 (50 mL) was stirred at room temp for 18 h. A white solid was provided as 4-(2-benzenesulfonylamino-thiazol-4-yl)-benzoic acid methyl ester.