Triethylamine → N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)-2-(6-trifluoromethylquinazolin-4-ylamino)acetamide

HRID 130382ノート

反応式

HRID 130382 の反応式
[NH2:1][CH2:2][C:3]([NH:5][CH:6]1[CH2:16][CH:9]2[CH2:10][N:11]([CH:13]([CH3:15])[CH3:14])[CH2:12][CH:8]2[CH:7]1[CH2:17][O:18][CH3:19])=[O:4].Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([C:31]([F:34])([F:33])[F:32])[CH:29]=2)[N:24]=[CH:23][N:22]=1.C(N(CC)CC)C>C(O)C>[CH:13]([N:11]1[CH2:12][CH:8]2[CH:7]([CH2:17][O:18][CH3:19])[CH:6]([NH:5][C:3](=[O:4])[CH2:2][NH:1][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([C:31]([F:33])([F:34])[F:32])[CH:29]=4)[N:24]=[CH:23][N:22]=3)[CH2:16][CH:9]2[CH2:10]1)([CH3:14])[CH3:15]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 210750954-Chloro-6-(trifluoromethyl)quinazolineHCID 692215432-amino-N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)acetamide

生成物 1

HCID 69224927N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)-2-(6-trifluoromethylquinazolin-4-ylamino)acetamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-amino-N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)acetamide, 4-chloro-6-trifluoromethylquinazoline (see Armarego et al., J. Chem. Soc. B, 1967, 449) and triethylamine in ethanol is heated at reflux until the reaction is complete. The solution is concentrated under vacuum yielding a residue. The residue is purified by reverse phase HPLC and lyophilization providing the title product.

後処理

  1. temperatureis heated
  2. temperatureat reflux until the reaction
  3. concentrationThe solution is concentrated under vacuum
  4. customyielding a residue
  5. customThe residue is purified by reverse phase HPLC and lyophilization

出典と根拠

ORDレコード
ord-9e161f22675b48dda1bbf83ba3010999
出典データセット
uspto-grants-2008_06
特許番号
US07381738B2

反応ノート

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