2-Chloromandelic acid → (S(R,R))-2-amino-1-phenylpropane-1,3-diol

HRID 130611

反応式

[OH:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Cl:12])[C:3]([OH:5])=[O:4].[C:13]1([C@H:19]([OH:24])[C@@H:20]([NH2:23])[CH2:21][OH:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(OC(=O)C)C.O>[OH:1][C@@H:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Cl:12])[C:3]([O-:5])=[O:4].[C:13]1([C@H:19]([OH:24])[C@@H:20]([NH2:23])[CH2:21][OH:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

実験手順

(The compound of the general formula (II)—wherein R1 is a hydroxy-methyl group, R2 is a phenyl group, R3 is a hydroxy group) Racemic 2-hydroxy-2-(2-chlorophenyl)acetic acid (20.0 g 107 mmol) was dissolved in 60 cm3 of ethylacetate saturated with water and (1S, 2S)-(+)-1-phenyl-2-amino-1,3-propane-diol (18.0 g 107.5 mmol) was added thereto and then the mixture was seed by a salt formed from (S)-(+)-2-hydroxy-2-(2-chlorophenyl)acetate and (1S, 2S)-(+)-1-phenyl 2-amino-1,3-propane-diol at room temperature.

後処理

additionwas added

出典と根拠

ORDレコード: ord-905f9881af514c839e3efb384d85a9ad
出典データセット: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07381835B2

反応式

参加物

反応物 2

生成物 2

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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