関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| 反応物 | 5-Amino-2-methylindole | HCID 2733992 | — |
| 反応物 | Dichloroethane ethanol | HCID 18381953 | — |
| 生成物 | N-(2-methyl-1H-indol-5-yl)-7-(trifluoromethyl)quinolin-4-amine | HCID 59730772 | 17.2% |
反応手順
A suspension of 4-chloro-7-(trifluoromethyl)quinoline 1-A (158 mg, 0.68 mmol), 2-methyl-1H-indol-5-amine 1-B (100 mg, 0.68 mmol) and 4N HCl in dioxane (0.25 ml, 1.0 mmol) in a mix solvent (EtOH/dichloroethane, 1:1, 6 ml) was heated to 90° C. in a sealed tube overnight. The reaction mixture was concentrated and dissolved in 2 ml of DMSO. The solution was purified by HPLC (DionexSystem, 20-60% CH3CN/H2O over 30 minutes). 40 mg of N-(2-methyl-1H-indol-5-yl)-7-(trifluoromethyl)quinolin-4-amine 1 was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07381824B2 |
|---|
| 出典データセット | uspto-grants-2008_06 |
|---|
| ORD ID | ord-97edca1ff174403b8d5ac887663ba404 |
|---|
| 出典メモ | uspto-grants-2008_06 |
|---|
