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N,N-Dimethylethylenediamine → N,N-dimethyl-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylethylenediamine | HCID 66053 | — |
| 反応物 | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| 反応物 | Ethane, azido- | HCID 79118 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N,N-dimethyl-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine | HCID 3696952 | — |
反応手順
To a solution of 2-chloro-5-nitropyridine 106-A and EtN3 (4.7 g, 46.5 mmol) in CH3CN (150 ml) was added N,N-dimethylethlenediamine 106-B (4.1 g, 46.5 mmol). The solution was stirred at room temperature for 3 hours, extracted with EtOAc, washed (brine), dried(MgSO4) and concentrated to give N,N-dimethyl-N′-(5-nitropyridin-2-yl)ethane-1,2-diamine 106-C (5.2 g) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07381824B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-3632a75afb1e4d6bab2873d1474fea9c |
| 出典メモ | uspto-grants-2008_06 |