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Sodium hydride → 5-(4-[1,3]Dioxolan-2-ylphenoxy)pyridine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-[1,3]dioxolan-2-ylphenol | HCID 11321164 | — |
| 反応物 | 5-Fluoropyridine-2-carboxamide | HCID 21904754 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(4-[1,3]Dioxolan-2-ylphenoxy)pyridine-2-carboxamide | HCID 68749528 | — |
反応手順
Dissolve 4-[1,3]dioxolan-2-ylphenol (Part C2, 0.471 g, 2.85 mmol) in DMF (89.5 mL). Add NaH (80% in mineral oil) (0.128 g, 4.28 mmol). Stir at room temperature for about an hour before adding 5-fluoropyridine-2-carboxamide (0.400 g, 2.85 mmol). Heat at 80° C. for 4.5 hours before concentrating to dryness to form 5-(4-[1,3]dioxolan-2-ylphenoxy)pyridine-2-carboxamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07381719B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-a3e46bba254348b2973c86384e1449e7 |
| 出典メモ | uspto-grants-2008_06 |