4-(1,3-Dioxolan-2-yl)-2-methoxyphenol → 5-(4-Formyl-2-methoxyphenoxy)pyridine-2-carboxamide

関与物質

反応手順

Using a method similar to Example 388 Part D, using 5-fluoropyridine-2-carboxamide (Example 388 Part C) (0.400 g, 2.85 mmol) and 4-[1,3]dioxolan-2-yl-2-methoxyphenol (Example 386, Part C2) (0.560 g, 2.85 mmol) gives the title compound (0.126 g, 16%): MS ES+ 272.9 (M+H)+; HPLC [YMC-Pack Pro C-18 (150×4.6 min, S-5 microm). 0.1% TFA/acetonitrile in 0.1% TFA/water at 1.0 mL/min. 5-95% over 19 min], tR=11.1 min. 97.2% purity.

情報源と証拠