関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | l-Valine, ethyl ester | HCID 87182 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl 2-(4-nitrophenylamino)-3-methylbutyrate | HCID 58596142 | 32.7% |
反応手順
162 mg of 4-fluoronitrobenzene, 200 mg of L-valine ethyl ester and 0.4 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone (NMP). The reaction medium was heated at 70° C. for 8 hours and, after cooling to room temperature, then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 100 mg of ethyl 2-(4-nitrophenylamino)-3-methylbutyrate (8) were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07384432B2 |
|---|
| 出典データセット | uspto-grants-2008_06 |
|---|
| ORD ID | ord-a406a4bad6cf4634999741d2ef7864de |
|---|
| 出典メモ | uspto-grants-2008_06 |
|---|
