関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | L-Alanine 1,1-dimethylethyl ester | HCID 89016 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Tert-butyl 2-(4-nitrophenylamino)propionate | HCID 58596136 | 33.6% |
反応手順
388 mg of 4-fluoronitrobenzene, 500 mg of L-alanine tert-butyl ester and 0.9 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone. The reaction medium was heated at 70° C. for 20 hours and, after cooling to room temperature, then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 246 mg of tert-butyl 2-(4-nitrophenylamino)propionate (10) were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07384432B2 |
|---|
| 出典データセット | uspto-grants-2008_06 |
|---|
| ORD ID | ord-79adefcb38fd4457bda61c8c9d8bb863 |
|---|
| 出典メモ | uspto-grants-2008_06 |
|---|
