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Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Phosphorodichloridous acid, 2-cyanoethyl ester | HCID 195897 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite | HCID 2734844 | — |
反応手順
To a solution of 1.9 mL (1 3.8 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 2.3 mL (13.8 mmol) of diisopropylamine under Argon. The reaction by mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for next step reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384749B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-2f2b1cbbf86d4296add64e3c31a8121b |
| 出典メモ | uspto-grants-2008_06 |