Diisopropylethylamine → N-[6-(2,4-dichlorophenyl)-5-nitropyrazin-2-yl]-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine

関与物質

役割	名称	HCID	仕込み量
反応物	Diisopropylethylamine	HCID 81531	—
反応物	2-(2-Aminoethylamino)-5-nitropyridine	HCID 122425	—
反応物	3-(2,4-Dichlorophenyl)-5-bromo-2-nitropyrazine	HCID 22318510	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	N-[6-(2,4-dichlorophenyl)-5-nitropyrazin-2-yl]-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine	HCID 10182377	—

反応条件

温度	80 °C

反応手順

To a solution of 3-(2,4-dichlorophenyl)-5-bromo-2-nitropyrazine (20 mg, 0.057 mmol) in DMF (1 ml), (2-aminoethyl)(5-nitro(2-pyridyl))amine (11.3 mg, 0.06 mmol) and diisopropylethyl amine (40 μl, 0.228 mmol) were added. The reaction mixture was stirred for 12 hours at 80° C. The crude mixture was concentrated in vacuo and subjected to column chromatography (5% methanol in methylene chloride) to afford the title compound as bright yellow solid.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07384942B2
出典データセット	uspto-grants-2008_06
ORD ID	ord-eff91b92e2754da3a7dcb33f3f1f010e
出典メモ	uspto-grants-2008_06