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2-(Tributylstannyl)furan → 2-Chloro-4-(2-furyl)thieno[3,2-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Tributylstannyl)furan | HCID 4393688 | — |
| 反応物 | 2,4-Dichlorothieno[3,2-d]pyrimidine | HCID 12712832 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Chloro-4-(2-furyl)thieno[3,2-d]pyrimidine | HCID 59732387 | 52% |
反応手順
A solution of 2,4-dichlorothieno[3,2-d]pyrimidine (205 mg, 1 mmol) in DMF (4 mL) was treated with PdCl2(PPh3)2 (35 mg, 0.05 mmol) and 2-(tributylstannyl)-furan (315 μL, 1 mmol), stirred at room temperature for 16 h, the reaction mixture purified directly by chromatography (SiO2:EtOAc:Heptane, 1:9) and the resulting cream solid recrystallised (EtOAc/Heptane) to give the title compound (122 mg, 52%) as a cream solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384949B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-524460fa7ee648f19cd5ed6ace47b3f8 |
| 出典メモ | uspto-grants-2008_06 |