Hydrochloric Acid → HCID 178517399、化合物

HRID 131201

反応式

HRID 131201 の反応式
Cl.[NH2:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([O:10]C)=O.[CH:12]1([C:15]#[N:16])[CH2:14][CH2:13]1.[NH4+].[OH-]>O1CCOCC1.O>[CH:12]1([C:15]2[N:16]=[C:8]([OH:10])[C:4]3[S:5][CH:6]=[CH:7][C:3]=3[N:2]=2)[CH2:14][CH2:13]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 79637CyclopropanecarbonitrileHCID 89652Methyl 3-amino-2-thiophenecarboxylate

生成物 1

HCID 178517399HCID 178517399、化合物収率 72%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Dry HCl gas was bubbled through a solution of methyl 3-aminothiophene-2-carboxylate (1.64 g, 10.4 mmol) and cyclopropanecarbonitrile (27 mL) in dioxane (40 mL) for 1 h then the reaction mixture was diluted with cold water (2 volumes), basified with NH4OH (50 mL) and the resulting solid filtered and air dried to give the title compound (1.44 g, 72%) as a white solid: IR νmax (Nujol)/cm−1 2925, 1664, 1597, 788; NMR δH (400 MHz, DMSO) 1.04 (4H, m), 2.00 (1H, m), 7.20 (1H, d J 5.0 Hz), 8.10 (1H, d, J 5.0 Hz) and 12.60 (1H,br).

後処理

  1. filtrationthe resulting solid filtered
  2. customair dried

出典と根拠

ORDレコード
ord-ec448f144c3441c5b13a1991b7d268fa
出典データセット
uspto-grants-2008_06
特許番号
US07384949B2

関連ノート

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