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HRID 131209作成日：2026年10月26日
Hydrochloric Acid → 1-(4-Methoxy-benzyl)-2-phenoxymethyl-1H-benzoimidazole-5-carboxylic acid allyl ester
https://huagongshe.com/reaction/131209
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-[tert-Butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-3-(2-phenoxy-acetylamino)-benzoic acid allyl ester | HCID 68466940 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 1-(4-Methoxy-benzyl)-2-phenoxymethyl-1H-benzoimidazole-5-carboxylic acid allyl ester | HCID 68464256 | — |
反応手順
Crude 4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-3-(2-phenoxy-acetylamino)-benzoic acid allyl ester was dissolved in methanol and 4N HCl in dioxan added. The reaction was stirred at 40° C. for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 483.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07384945B2 |
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| 出典データセット | uspto-grants-2008_06 |
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| ORD ID | ord-a9bce4f8a9ab40b595f50233bacb5888 |
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| 出典メモ | uspto-grants-2008_06 |
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