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1-Naphthalenemethanamine → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid (naphthalen-1-ylmethyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Naphthalenemethanamine | HCID 8355 | — |
| 反応物 | Diisopropylcarbodiimide | HCID 12734 | — |
| 反応物 | 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid | HCID 68463846 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid (naphthalen-1-ylmethyl)-amide | HCID 68465697 | — |
反応手順
0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of naphthalen-1-ylmethyl-amine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 582.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384945B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-468145fb61a74f6a96c454d386e85829 |
| 出典メモ | uspto-grants-2008_06 |