Acetoin → 2-Amino-4,5-dimethyl-3-furancarbonitrile

HRID 131288

反応式

HRID 131288 の反応式
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[OH:6][CH:7]([CH3:11])[C:8](=O)[CH3:9].C(NCC)C>CO>[NH2:4][C:3]1[O:6][C:7]([CH3:11])=[C:8]([CH3:9])[C:2]=1[C:1]#[N:5]

参加物

5

反応物 3

HCID 179AcetoinHCID 8010MalononitrileHCID 8021Diethylamine

生成物 1

HCID 2902202-Amino-4,5-dimethyl-3-furancarbonitrile収率 75%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
10 °C

実験手順

To a solution of malononitrile (28.2 g) in methanol (30 mL) is added a suspension of acetoin (25 g) in methanol (30 mL) and thereto is added dropwise diethylamine (11 mL) under ice-cooling (internal temp.: 10° C.). The mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice water (300 mL) and the precipitated crystals are collected by filtration to give 2-amino-4,5-dimethyl-3-furonitrile (28.91 g, yield; 75%) as colorless crystals.

後処理

  1. filtrationthe precipitated crystals are collected by filtration

出典と根拠

ORDレコード
ord-e457f56050504f0fa27764bfa1e56fd1
出典データセット
uspto-grants-2008_06
特許番号
US07384952B2

関連ノート

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