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Dimethyl Sulfoxide → 6-Hydroxypyridazine-3-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | 1,4,5,6-Tetrahydro-6-oxo-3-pyridazinecarboxylic acid | HCID 99621 | — |
| 反応物 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-Hydroxypyridazine-3-carboxylic Acid | HCID 305970 | 54% |
反応手順
To a solution of 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid (20 g) in acetic acid (50 mL) is added 25% hydrobromic acid/acetic acid (200 mL) and thereto is added dropwise dimethylsulfoxide (22.0 g) at room temperature. The mixture is stirred at room temperature for 3 days. The resultant precipitates are collected by filtration, washed successively with acetic acid and water and dried at 40° C. overnight to give 6-oxo-1,6-dihydropyridazine-3-carboxylic acid (10.55 g, yield; 54%) as colorless crystals. MS (ESI) m/z: 139 [M−H]−
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384952B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-e94ef1afdff847aa87dcc79ed74fcb72 |
| 出典メモ | uspto-grants-2008_06 |