Methanol → Methyl 4-sulfanylbenzoate

HRID 131298

反応式

HRID 131298 の反応式
[SH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:16]O>>[SH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 957384-Mercaptobenzoic acid

生成物 1

HCID 237573Methyl 4-sulfanylbenzoate収率 99%

実験手順

To a solution of 4-mercaptobenzoic acid (1.5 g) in methanol (20 mL) is added conc. sulfuric acid (0.5 mL) and the mixture is refluxed under heating overnight. The reaction mixture is evaporated to remove solvent and the residue is neutralized with a saturated sodium hydrogencarbonate solution. The mixture is extracted with ethyl acetate and the extract is concentrated in vacuo to give methyl 4-mercaptobenzoate (1.6 g, yield; 99%) as a colorless oil. MS (APCI) m/z: 167 [M−H]−

後処理

  1. temperaturethe mixture is refluxed
  2. temperatureunder heating overnight
  3. customThe reaction mixture is evaporated
  4. customto remove solvent
  5. extractionThe mixture is extracted with ethyl acetate
  6. concentrationthe extract is concentrated in vacuo

出典と根拠

ORDレコード
ord-f51b70acb2e7448bbb18b4a5d91736aa
出典データセット
uspto-grants-2008_06
特許番号
US07384952B2

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