化工社化工社 化学情報印刷レポート · 研究参考用
Stannous Chloride → 8-Fluoro-2-isopropyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 2-(4-Fluoro-2-nitro-phenylamino)-5-isopropyl-benzonitrile | HCID 21093459 | — |
| 反応物 | 8-Fluoro-2-methyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride | HCID 135797761 | — |
| 生成物 | 8-Fluoro-2-isopropyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride | HCID 135797759 | 74% |
反応手順
Using a similar procedure as found for 8-fluoro-2-methyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride, using 2-(4-fluoro-2-nitro-phenylamino)-5-isopropyl-benzonitrile (0.559 g, 1.87 mmol), tin (II) chloride(1.06 g, 5.60 mmol) to obtain the title compound (0.422 g, 1.38 mmol, 74% yield) as a yellow amorphous solid: Mass Spectrum (m/e): 270(M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384934B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-8d86a4e840054dacb9e74a82457b166c |
| 出典メモ | uspto-grants-2008_06 |