(S)-6-fluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride → (S)-6,7-Difluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride

HRID 131475

反応式

HRID 131475 の反応式
[ClH:1].Cl.[F:3][C:4]1[CH:5]=[CH:6][C:7]2[N:16]=[C:15]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[C@@H:19]([CH2:24][CH2:25][O:26][CH3:27])[CH2:18]3)[C:14]3[CH:13]=[C:12]([CH2:28]C)[S:11][C:10]=3[NH:9][C:8]=2[CH:30]=1.Cl.[F:32]C1C(F)=CC2N=C(N)C3C=C(C)SC=3NC=2C=1>>[ClH:1].[ClH:1].[F:3][C:4]1[C:5]([F:32])=[CH:6][C:7]2[N:16]=[C:15]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[C@@H:19]([CH2:24][CH2:25][O:26][CH3:27])[CH2:18]3)[C:14]3[CH:13]=[C:12]([CH3:28])[S:11][C:10]=3[NH:9][C:8]=2[CH:30]=1

参加物

3

反応物 2

HCID 69211696(S)-6-fluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochlorideHCID 1363885776,7-Difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride

生成物 1

HCID 136384257(S)-6,7-Difluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride

実験手順

Using a method similar to the example (S)-6-fluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride, using 6,7-difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride and (S)-2-(2-methoxy)ethylpiperazine: 1H NMR (DMSO-d6): δ 11.7110 (2H, bs), 9.3793 (1H, bs), 7.3795 (1H, bs), 7.0701 (1H, bt), 6.6326 (1H, bs), 4.1000 (3H, bm), 3.6041 (3H, bs), 3.4347 (3H, bs), 3.2081 (3H, bs), 2.8371 (3H, bs), 2.3319 (3H, bs), 2.2842 (1H, bm), 1.8410 (1H, bs); Mass Spectrum M+H=407.1.

出典と根拠

ORDレコード
ord-ece814ab905142ab83618c5e12eb4934
出典データセット
uspto-grants-2008_06
特許番号
US07384934B2

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