Dimethylformamide → HCID 86760682、化合物

HRID 131565

反応式

HRID 131565 の反応式
Cl[C:2]1[N:3]=[C:4]([CH3:33])[N:5]([CH2:8][C:9]2[S:24][C:12]3[N:13]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:14](=[O:19])[N:15]([CH3:18])[C:16](=[O:17])[C:11]=3[C:10]=2[C:25](N2C[C@H](O)CO2)=[O:26])[C:6]=1Cl.OCC1N[C:38]2[CH:44]=[CH:43][CH:42]=CC=2N=1.[C:45](=O)([O-])[O-:46].[K+].[K+].CN(C=[O:55])C>>[OH:55][CH2:33][C:4]1[N:5]([CH2:8][C:9]2[S:24][C:12]3[N:13]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:14](=[O:19])[N:15]([CH3:18])[C:16](=[O:17])[C:11]=3[C:10]=2[C:25]([O:46][CH3:45])=[O:26])[C:6]2[CH:38]=[CH:44][CH:43]=[CH:42][C:2]=2[N:3]=1

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 785692-(Hydroxymethyl)-1H-benzimidazoleHCID 10142559HCID 10142559、化合物

生成物 1

HCID 86760682HCID 86760682、化合物

実験手順

The product of example 3 part b) (0.6 g,) was dissolved in DMF (5 ml). 2-Hydroxymethyl-benzimidazole (0.28 g,) and anhydrous potassium carbonate (0.6 g) were added to the solution, which was stirred for 16 h. The sub-title compound was obtained as a white solid after filtration of the reaction mixture and evaporation (0.18 g). MS (APCI) 457 [M+H]+. δ 1HCDCl3 0.87 (3H,s), 0.9 (3H,s), 2.1-2.2 (m, 1H), 3.38 (s,3H), 3.57-3.64 (m,3H), 3.96 (s,3H), 4.97 (s,2H), 5.64 (s,2H), 7.26-7.38 (m,2H), 7.22-7.3 (m,1H) and 7.74-7.8 (m,1H).

出典と根拠

ORDレコード
ord-8ce2a44baf4c4238a7f1a5e25c79a9f7
出典データセット
uspto-grants-2008_06
特許番号
US07384950B2

関連ノート

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