反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[NH2:23][C:24]1[CH:25]=[C:26]([CH:32]=[CH:33][CH:34]=1)[CH2:27][NH:28][C:29](=[O:31])[CH3:30]>>[C:29]([NH:28][CH2:27][C:26]1[CH:25]=[C:24]([NH:23][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:15][CH:16]=2)=[O:21])[CH:34]=[CH:33][CH:32]=1)(=[O:31])[CH3:30]参加物
3
実験手順
N-[3-(Acetylaminomethyl)phenyl]-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and N-(3-aminobenzyl)acetamide using method J. NMR; δH [2H6]—DMSO 10.34,(1H, b), 8.38,(1H, t), 8.06,(2H, d), 7.91,(1H, dd), 7.79,(1H, d), 7.70,(2H, m), 7.57,(3H, m), 7.30,(1H, t), 7.00,(1H, d), 4.25,(2H, d), 2.57,(3H, s), 2.34,(3H, s), 1.88,(3H, s). LCMS; retention time 3.07 min, MH+ 441.
出典と根拠
- ORDレコード
- ord-2a73748db4594c6eaaae816bd97bf54e
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07384963B2
関連ノート
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