4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid → 2'-Methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-[(3-phenylureido)methyl]phenyl}-1,1'-biphenyl-4-carboxamide

HRID 131672

反応式

HRID 131672 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[NH2:23][C:24]1[CH:25]=[C:26]([CH:38]=[CH:39][CH:40]=1)[CH2:27][NH:28][C:29]([NH:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:30]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([NH:23][C:24]2[CH:40]=[CH:39][CH:38]=[C:26]([CH2:27][NH:28][C:29]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[O:30])[CH:25]=2)=[O:21])=[CH:18][CH:19]=1

参加物

3

反応物 2

HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic AcidHCID 59190887N-(3-aminobenzyl)-N'-phenylurea

生成物 1

HCID 102296412'-Methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-[(3-phenylureido)methyl]phenyl}-1,1'-biphenyl-4-carboxamide

実験手順

2′-Methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-{3-[(3-phenylureido)methyl]phenyl}-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and N-(3-aminobenzyl)-N′-phenylurea using method J. NMR; δH [2H6]—DMSO 10.36,(1H, b), 8.57,(1H, s), 8.06,(2H, d), 7.90,(1H, dd), 7.78,(2H, m), 7.69,(1H, dd), 7.57,(3H, m), 7.39,(3H, m), 7.21,(2H, m), 7.05,(1H, d), 6.62,(1H, t), 4.31,(2H, d), 2.57,(3H, s), 2.33,(3H, s). LCMS; retention time 3.55 min, MH+ 518.

出典と根拠

ORDレコード
ord-2b9e7fc1a92849c79815f7a82b4e5c7b
出典データセット
uspto-grants-2008_06
特許番号
US07384963B2

関連ノート

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