tert-butyl N-((3-aminophenyl)methyl)carbamate → N-{3-[(t-Butoxycarbonylamino)methyl]phenyl}2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[C:23]([O:27][C:28]([NH:30][CH2:31][C:32]1[CH:33]=[C:34]([CH:36]=[CH:37][CH:38]=1)[NH2:35])=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[C:23]([O:27][C:28]([NH:30][CH2:31][C:32]1[CH:33]=[C:34]([NH:35][C:20]([C:17]2[CH:16]=[CH:15][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:19][CH:18]=2)=[O:22])[CH:36]=[CH:37][CH:38]=1)=[O:29])([CH3:26])([CH3:24])[CH3:25]参加物
3
実験手順
N-{3-[(t-Butoxycarbonylamino)methyl]phenyl}2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1 ′-biphenyl-4-carboxylic acid and 3-[(t-butoxycarbonylamino)-methyl]aniline using method J. NMR; δH [2H6]—DMSO 10.34,(1H, b), 8.06,(2H, d), 7.91,(1H, dd), 7.79,(1H, d), 7.70,(1H, s), 7.66,(1H, d), 7.59-7.56,(3H, m), 7.41,(1H, t), 7.29,(1H, t), 6.98,(1H, d), 4.14,(2H, d), 2.57,(3H, s), 2.34,(3H, s), 1.40,(9H, s). LCMS; retention time 3.59 min, [M-H]− 497.