4-(Aminomethyl)benzenemethanesulfonamide → HCID 10116447、化合物
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[NH2:23][CH2:24][C:25]1[CH:35]=[CH:34][C:28]([CH2:29][S:30]([NH2:33])(=[O:32])=[O:31])=[CH:27][CH:26]=1>>[NH2:33][S:30]([CH2:29][C:28]1[CH:34]=[CH:35][C:25]([CH2:24][NH:23][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:15][CH:16]=2)=[O:22])=[CH:26][CH:27]=1)(=[O:31])=[O:32]参加物
3
実験手順
N-[4-(Aminosulphonylmethyl)benzyl]-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 4-(aminomethyl)benzylsulphonamide using method H. NMR; δH [2H6]—DMSO 9.17,(1H, t), 8.00,(2H, d), 7.89,(1H, dd), 7.76,(1H, d), 7.56-7.51,(3H, m), 7.33,(4H, m), 6.82,(2H, b), 4.50,(2H, d), 4.23,(2H, s), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 2.90 min, MH+ 477.
出典と根拠
- ORDレコード
- ord-f6d51bfcacbb4463b92ff2661c04be72
- 出典データセット
- uspto-grants-2008_06
- DOI