Hydrochloric Acid → 4-(5-Iodoindazole-1-yl)-benzoic acid

HRID 13177

反応式

HRID 13177 の反応式
F[C:2]1[CH:19]=[CH:18][C:17]([I:20])=[CH:16][C:3]=1[CH:4]=[N:5][NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1.CC(C)([O-])C.[K+].Cl>CN1C(=O)CCC1.O>[I:20][C:17]1[CH:16]=[C:3]2[C:2](=[CH:19][CH:18]=1)[N:6]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1)[N:5]=[CH:4]2

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 23665647Potassium tert-butoxideHCID 668129224-(2-(2-Fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

生成物 1

HCID 593397454-(5-Iodoindazole-1-yl)-benzoic acid収率 94.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (141d, 3.42 g, 8.9 mmol) and potassium tert-butoxide (2.29 g, 20.5 mmol) was stirred under argon atmosphere in NMP (45 mL) at 150° C. for 15 min. The mixture was then cooled, diluted with water and acidified with aqueous HCl (1.7 M). The precipitate that formed was collected by filtration and dried in vacuo to give crude 4-(5-iodo-1H-indazol-1-yl)benzoic acid (3.05 g, 94%)

後処理

  1. temperatureThe mixture was then cooled
  2. customThe precipitate that formed
  3. filtrationwas collected by filtration
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-b0a180ffdb6a4a968061697b297c7dd0
出典データセット
uspto-grants-2010_06
特許番号
US07728030B2

関連ノート

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