2-Aminothiazole → N-[2-(3,4-Methylenedioxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea

HRID 131797

反応式

HRID 131797 の反応式
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([OH:10])=[CH:4][C:3]=2[O:2]1.F[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-:20])=[O:19].[CH2:21]1[O:37][C:36]2[CH:35]=[CH:34][C:25]([O:26][C:27]3[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=3[NH2:29])=[CH:24][C:23]=2[O:22]1.[NH2:38][C:39]1[S:40][CH:41]=[CH:42][N:43]=1>>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([O:10][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N+:18]([O-:20])=[O:19])=[CH:4][C:3]=2[O:2]1.[CH2:21]1[O:37][C:36]2[CH:35]=[CH:34][C:25]([O:26][C:27]3[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=3[NH:29][C:5]([NH:38][C:39]3[S:40][CH:41]=[CH:42][N:43]=3)=[O:10])=[CH:24][C:23]=2[O:22]1

参加物

6

反応物 4

HCID 21552-AminothiazoleHCID 68289SesamolHCID 738951-Fluoro-2-nitrobenzeneHCID 284018912-(3,4-Methylenedioxyphenoxy)aniline2 回

生成物 2

HCID 77789392-(3,4-Methylenedioxyphenoxy)-1-nitrobenzene収率 58%HCID 59732860N-[2-(3,4-Methylenedioxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea収率 68%

実験手順

2-(3,4-Methylenedioxyphenoxy)-1-nitrobenzene (0.75 g, 58%) was prepared from 3,4-methylenedioxyphenol (0.76 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(3,4-methylenedioxyphenoxy)aniline (0.47 g, 71%) following general procedure B. N-[2-(3,4-Methylenedioxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (120 mg, 68%) was prepared from 2-(3,4-methylenedioxyphenoxy)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-26025d21380942acbeb4a2c8c00ce33d
出典データセット
uspto-grants-2008_06
特許番号
US07384967B2

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