化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(2-Methylsulfanylphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | o-(Methylthio)phenol | HCID 61261 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(2-Methylsulfanylphenoxy)aniline | HCID 59783707 | — |
| 生成物 | N-[2-(2-Methylsulfanylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732701 | 65% |
| 生成物 | 2-(2-Methylsulfanylphenoxy)-1-nitrobenzene | HCID 59783615 | 68% |
反応手順
2-(2-Methylsulfanylphenoxy)-1-nitrobenzene (0.88 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-methylsulfanylphenoxy)aniline (0.53 g, 68%) following general procedure B. N-[2-(2-Methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (115 mg, 65%) was prepared from 2-(2-methylsulfanylphenoxy)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-a5b2c6c177434d60bc514402f4b1d0c9 |
| 出典メモ | uspto-grants-2008_06 |