化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → HCID 66998130、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2,6-Difluorophenol | HCID 94392 | — |
| 反応物 | HCID 66999006 | HCID 66999006 | — |
| 生成物 | N-[2-(2,6-difluorophenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732807 | 60% |
| 生成物 | HCID 66998130 | HCID 66998130 | 70% |
反応手順
2-(2,6-difluorophenoxy)-1-nitrobenzene (0.44 g, 70%) was prepared from 2,6-difluorophenol (0.32 g, 2.5 mmol) and 1-fluoro-2-nitrobenzene (0.36 g, 2.5 mmol) following the general procedure A. This was reduced to 2-(2,6-difluorophenoxy)aniline (0.24 g, 60%) following general procedure B. N-[2-(2,6-difluorophenoxy)phenyl]-N′-(thiazol-2-yl)urea (133 mg, 60%) was prepared from 2-(2,6-difluorophenoxy)aniline (206 mg, 0.9 mmol) and 2-aminothiazole (405 mg, 2.5 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-a1f1626cd9b04dcbbdde508ee6fbec99 |
| 出典メモ | uspto-grants-2008_06 |