化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(2-Fluoro-6-methoxyphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| 反応物 | 2-(2-Fluoro-6-methoxyphenoxy)aniline | HCID 66999003 | — |
| 生成物 | 1-(Thiazol-2-yl)urea | HCID 16781708 | 63% |
| 生成物 | 2-(2-Fluoro-6-methoxyphenoxy)-1-nitrobenzene | HCID 66998218 | 64% |
反応手順
2-(2-Fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.84 g, 64%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-fluoro-6-methoxyphenoxy)aniline (0.63 g, 85%) following general procedure C. N-2-(2-Fluoro-6-methoxyphenoxy)phenyl)-N′-(thiazol-2-yl)urea (114 mg, 63%) was prepared from 2-(2-fluoro-6-methoxyphenoxy)aniline (117 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-63a7cf7646a44658bf432dcbe8a7c08c |
| 出典メモ | uspto-grants-2008_06 |