化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | o-(Methylthio)phenol | HCID 61261 | — |
| 反応物 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 反応物 | 5-Fluoro-2-(2-methylsulfanylphenoxy)aniline | HCID 63648471 | — |
| 生成物 | N-[5-Fluoro-2-(2-methylsulfanylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732844 | 65% |
| 生成物 | 5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene | HCID 66998972 | 68% |
反応手順
5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene (0.95 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-methylsulfanylphenoxy)aniline (0.52 g, 62%) following general procedure B. N-[5-Fluoro-2-(2-methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (120 mg, 65%) was prepared from 5-fluoro-2-(2-methylsulfanylphenoxy)aniline (125 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-83e24de0a2a043358d41ef8be1d9a45f |
| 出典メモ | uspto-grants-2008_06 |