化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 3-(2,3-Dimethoxyphenoxy)-4-nitrotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 反応物 | 2-(2,3-Dimethoxyphenoxy)-4-methylaniline | HCID 66998836 | — |
| 生成物 | N-[2-(2,3-Dimethoxyphenoxy)-4-methylphenyl]-N'-(thiazol-2-yl)urea | HCID 59733062 | 63% |
| 生成物 | 3-(2,3-Dimethoxyphenoxy)-4-nitrotoluene | HCID 66998924 | 64% |
反応手順
3-(2,3-Dimethoxyphenoxy)-4-nitrotoluene (0.92 g, 64%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 3-fluoro-4-nitrotoluene (0.78 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-4-methylaniline (0.65 g, 79%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-4-methylphenyl]-N′-(thiazol-2-yl)urea (120 mg, 63%) was prepared from 2-(2,3-dimethoxyphenoxy)-4-methylaniline (130 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-4e00fe853d1344ffaeef48f6661a94a3 |
| 出典メモ | uspto-grants-2008_06 |