化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2,4-Difluorobenzene-1-thiol | HCID 2737073 | — |
| 反応物 | 2-(2,4-Difluorophenylsulfanyl)aniline | HCID 43345446 | — |
| 生成物 | 2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene | HCID 52479353 | 78% |
| 生成物 | 1-[2-(2,4-Difluorophenylsulfanyl)phenyl]-3-(thiazol-2-yl)urea | HCID 59732885 | 72% |
反応手順
2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene (1.04 g, 78%) was prepared from 2,4-difluorothiophenol (0.73 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,4-difluorophenylsulfanyl)aniline (0.64 g, 70%) following the general procedure B. 1-[2-(2,4-Difluorophenylsulfanyl)phenyl]-3-(thiazol-2-yl)urea (130 g, 72%) was prepared from 2-(2,4-difluorophenylsulfanyl)aniline (118 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-13e97d8c3b0f4bd7b3aa9cd60c0cc269 |
| 出典メモ | uspto-grants-2008_06 |