化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → Benzene, 1-fluoro-2-[(2-nitrophenyl)thio]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-Fluorothiophenol | HCID 520216 | — |
| 反応物 | 2-(2-Fluorophenylsulfanyl)aniline | HCID 11850357 | — |
| 生成物 | Benzene, 1-fluoro-2-[(2-nitrophenyl)thio]- | HCID 11850287 | 83% |
| 生成物 | HCID 59733001 | HCID 59733001 | 75% |
反応手順
2-(2-Fluorophenylsulfanyl)nitrobenzene (1.03 g, 83%) was prepared from 2-fluorothiophenol (0.70 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-fluorophenylsulfanyl)aniline (0.65 g, 72%) following general procedure B. N-[2-(2-Fluorophenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (129 mg, 75%) was prepared from 2-(2-fluorophenylsulfanyl)aniline (107 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-782ed4d5a4c34964901422f06cd6ca0d |
| 出典メモ | uspto-grants-2008_06 |