化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(3,5-Dimethylphenylsulfanyl)nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 3,5-Dimethylbenzenethiol | HCID 117548 | — |
| 反応物 | 2-((3,5-Dimethylphenyl)thio)aniline | HCID 66998967 | — |
| 生成物 | N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea | HCID 59733126 | 74% |
| 生成物 | 2-(3,5-Dimethylphenylsulfanyl)nitrobenzene | HCID 66999017 | 78% |
反応手順
2-(3,5-Dimethylphenylsulfanyl)nitrobenzene (1.01 g, 78%) was prepared from 3,5-dimethylthiophenol (0.76 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3,5-dimethylphenylsulfanyl)aniline (0.64 g, 72%) following the general procedure B. N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (131 mg, 74%) was prepared from 2-(3,5-dimethylphenylsulfanyl)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-e41ede9e832c434b94b3d4104ebcbf1e |
| 出典メモ | uspto-grants-2008_06 |