化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(Cyclopentylmethoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | Cyclopentanemethanol | HCID 77195 | — |
| 反応物 | 2-(Cyclopentylmethoxy)aniline | HCID 19754712 | — |
| 生成物 | N-[2-(Cyclopentylmethoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732720 | 60% |
| 生成物 | 2-(Cyclopentylmethoxy)-1-nitrobenzene | HCID 66998904 | 80% |
反応手順
2-(Cyclopentylmethoxy)-1-nitrobenzene (443 mg, 80%) was prepared from cyclopentanemethanol (0.32 ml, 3.0 mmol) and 1-fluoro-2-nitrobenzene (0.36 g, 2.5 mmol) following the general procedure G. This was reduced to 2-(cyclopentylmethoxy)aniline (268 mg, 70%) following general procedure B. N-[2-(Cyclopentylmethoxy)phenyl]-N′-(thiazol-2-yl)urea (286 mg, 60%) was prepared from 2-(cyclopentylmethoxy)aniline (0.25 g, 1.5 mmol) and 2-aminothiazole (150 mg, 1.5 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-92b0c447208c44e08a1489467c195453 |
| 出典メモ | uspto-grants-2008_06 |